Fatemeh Talaee Boura; Simin Mouodi; Reza Ghadimi; Ali Bijani
Volume 23, Issue 1 , 2021
Abstract
Background: The global incidence rate of frailty syndrome among older adults aged 60 years and over has been estimated to be 43.4 cases per 1000 persons/years.
Objectives: This study aimed to determine the prevalence of pre-frailty and frailty syndromes in community-dwelling older adults and assess ...
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Background: The global incidence rate of frailty syndrome among older adults aged 60 years and over has been estimated to be 43.4 cases per 1000 persons/years.
Objectives: This study aimed to determine the prevalence of pre-frailty and frailty syndromes in community-dwelling older adults and assess the correlated sociodemographic factors.
Methods: All elderly people recruited in the second phase of the Amirkola Health and Ageing Cohort Project, including 2135 older adults aged ?60 years living in Amirkola, North of Iran, were invited to participate in this study using the census method. The standard "FRAIL" scale was used to assess the frailty syndrome. The individuals who obtained a score of three or more and one or two were classified as frail and pre-frail cases, respectively.
Results: Totally, 2010 older adults with a mean age of 70.41±7.65 years were included in this study. Out of them, 672 (33.4%; 95% CI: 31.37-35.50%) cases met the criteria for frailty syndrome, and 874 (43.5%) individuals were regarded as pre-frail. The prevalence of frailty was significantly higher in females (50.8%; 95% CI: 47.58-54.05%), compared to males (18.7%; 95% CI: 16.41-21.05%). Multivariate logistic regression analysis revealed that age ?85 (OR=7.27; 95% CI: 4.12-24.46) and female gender (OR=2.67; 95% CI: 2.30-9.95) had the highest effect on frailty in older adults.
Conclusion: One out of every three elderly people (aged ?60) in Amirkola, North of Iran, had frailty syndrome. Older age, female gender, lower education level, low level of satisfaction with income, marital status (single), living alone, and unemployment increased the risk of frailty in older adults.
Jila Masrour-Roudsari; Mohammad Reza Hasanjani Roushan; Yousef Yahyapour; Rahim Barari Savadkoohi; Ali Bijani; Mousa Mohammadnia-Afrouzi
Volume 22, Issue 11 , 2020
Abstract
Background: Hepatitis B is a viral disease that can be chronic. The Treg population during hepatitis appears to have an important role in controlling disease progression.
Objectives: The present study aimed to determine the level of Tregs in patients with chronic hepatitis B (CHB) at different stages ...
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Background: Hepatitis B is a viral disease that can be chronic. The Treg population during hepatitis appears to have an important role in controlling disease progression.
Objectives: The present study aimed to determine the level of Tregs in patients with chronic hepatitis B (CHB) at different stages of the disease.
Methods: This study was carried out on 90 patients with CHB followed-up for an average of 10 years and divided into hepatitis B surface antigen (HBs Ag+), seroconverted (HBs Ag- and hepatitis B surface antibody [HBs Ab+]), and serocleared (HBs Ag- and HBs Ab-) groups. Then, 5 ml of the blood sample was taken, and the peripheral blood mononuclear cells (PBMCs) were separated using Ficoll. The surface markers, including CD4, CD25, and CD127, and FoxP3 intracellular marker were measured in the PBMCs. Isotype was considered the control for each sample. The samples were read by the FACSCalibur 4-color flow cytometer (BD Biosciences, San Jose, CA, USA) and analyzed using FlowJo software (version 7.6.1). The levels of aspartate aminotransferase, alanine transaminase, ?-fetoprotein, platelets, white blood cells, and hemoglobin were extracted from the patients records.
Results: The mean age values of the HBs Ag+ (n=35), seroclearance (n=27), and seroconversion (n=28) groups were 43.97±11.86, 47.26±12.95, and 47.39±10.40 years, respectively. The frequency of CD4+ CD25+ FoxP3+ (Treg) was higher in the HBs Ag+ group than that reported for the other two groups. The Treg population demonstrated a significant difference between the serocleared and seroconverted groups; however, the Treg frequency was higher in the seroconverted group in comparison to that of the other two groups. The Treg/T-Activator ratio was significantly higher in the HBs Ag+ group than those reported for the two other groups.
Conclusion: CD4+ CD25+ FoxP3+ T cells are the important subgroups of Treg cells affecting immune suppression.
Seyed Reza Hosseini; Zahra Zohani; Ali Bijani MD; Farzan Kheyrkhah; Ali Zabihi
Volume 22, Issue 8 , 2020
Abstract
Background: Falling and chronic diseases are important health issues in elderly people and reduce the quality of life.
Objectives: This study aimed to investigate the relationship between chronic diseases and falling in the elderly people.
Methods: This cross-sectional study came from the first ...
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Background: Falling and chronic diseases are important health issues in elderly people and reduce the quality of life.
Objectives: This study aimed to investigate the relationship between chronic diseases and falling in the elderly people.
Methods: This cross-sectional study came from the first phase of Amirkola Health and Ageing Project (AHAP) that has been done on all elderly people aged 60 and over in Amirkola city in northern part of Iran. Demographic information including chronic diseases were gathered through self-report, observation of prescriptions and consumed drugs by patients and prevalence of falling during 12 months ago was obtained through information form and interview with elderly people.
Results: In this study, 883 men(54.6%) and 733 women(45.3%) were investigated. The average age of individuals was 69.37±7.42 (in men 70±7.7 and in women 69.7±7.00). In this study, 288(17.8%) of eldely people had the experience of falling in the last 12 months. The prevalence of falling was higher in elderly women(P<0.001) and the elderly who lived alone(P=0.01). The prevalence of falling in the elderly had a significant relationship with diseases of osteoporosis(P<0.001), myocardial infarction(P=0.03), fractures(P<0.001), cognitive impairment(P=0.001), headache(P=0.002). In addition, the results of logistic regression showed that the prevalence of falling was related to urinary incontinence(P=0.02), fracture history(P=0.001), hearing loss(P=0.006), and depressive symptoms(P=0.001).
Conclusions: The results of this study indicate a significant prevalence of falling and its direct relation with some chronic diseases. Therefore, it is necessary to ask some questions and care about each referring of the elderly to the health centers.
